SyntheticOrganicChemistry

Course Information

College	Anan College	Year	2023
Course Title	SyntheticOrganicChemistry
Course Code	5517Z02	Course Category	Specialized / Compulsory
Class Format	Lecture	Credits	Academic Credit: 2
Department	Course of Applied Chemical Engineering	Student Grade	Adv. 2nd
Term	First Semester	Classes per Week	2
Textbook and/or Teaching Materials	Synthetic Organic Chemistry for Beginners (SANKYO SHUPPAN)
Instructor	Sugiyama Yuuki

Course Objectives

The goal of this course is not only to acquire the technical terms and knowledge used in the field of synthetic organic chemistry but also to be able to discuss and converse with them in an academic, industrial, or social sense and to acquire the ability to understand the current situation and discuss problems.

Rubric

	Ideal Level	Standard Level	Minimum Level
Objective 1	Electronic and steric effects can predict the relationship between structure and reactivity.	The relationship between structure and reactivity can be predicted by about 70% by electronic and steric effects.	The relationship between structure and reactivity can be predicted by about 50% by electronic and steric effects.
Objective 2	Based on the reaction mechanism, the products can be predicted.	Based on the reaction mechanism, about 70% of the products can be predicted.	Based on the reaction mechanism, about 50% of the products can be predicted.
Objective 3	Formulate a synthesis plan for a target compound.	Formulate a synthesis plan for about 70% of the target compounds.	Formulate a synthesis plan for about 50% of the target compounds.

Teaching Method

Outline:

To synthesize pharmaceuticals and materials, it is necessary to consider synthetic pathways by combining many synthetic reactions. This course will focus on stereo and electronic effects and learn basic and newest synthetic reactions. Students will review the organic chemistry learned in this course and learn the basic concepts and methods of organic synthetic chemistry.

Style:

Lectures and discussions will be given in the form of lectures and discussions. An assignment will be given for each lecture, and the discussion will be based on the study.

Notice:

Course Plan

			Theme	Goals
1st Semester
	1st Quarter
		1st	Organic synthetic chemistry	Explain the categorization of organic reactions.
		2nd	Approach to organic synthesis reaction 1	Explain the　atoms, molecular orbitals, resonances, acids, and bases.
		3rd	Approach to organic synthesis reaction 2	Explain organic reactions and electronic effects (I-effect).
		4th	Approach to organic synthesis reaction 3	Explain organic reactions and electronic effects (R-effect).
		5th	Approach to organic synthesis reaction 4	Explain organic reactions and steric effects.
		6th	Synthesis and reaction of hydrocarbons 1	Explain hydrogenation reactions, Clemensen reduction, and Wolf-Kishner reduction.
		7th	Synthesis and reaction of hydrocarbons 2	Explain Wittig reaction and Diels-Alder reaction.
		8th	Mid-term examination
	2nd Quarter
		9th	Alcohol synthesis and reaction	Explain the synthesis of alcohols and the many molecular transformation reactions of alcohols.
		10th	Synthesis and reaction of ethers and epoxides	Explain the synthesis of optically active alcohols and protective groups of alcohols.
		11th	Synthesis and reaction of carbonyl compounds 1	Explain the synthesis of ethers and epoxides, Williamson ether synthesis, and ring-opening reactions of epoxides.
		12th	Synthesis and reaction of carbonyl compounds 2	Explain Grignard reaction, Michael addition reaction, and Aldol reaction.
		13th	Synthesis and reaction of amines derivatives	Explain Baeyer-Viliger oxidation and malonate ester synthesis.
		14th	Synthesis and reaction of aromatic compounds 1	Explain Mannich reaction, and Hofmann rearrangement of amides.
		15th	Synthesis and reaction of aromatic compounds 2	The orientation of the substituents allows us to formulate a strategy for synthesizing aromatics.
		16th	Return and explanation of final examination

Evaluation Method and Weight (%)

	Examination	Quiz	Portfolio	Presentation and Attitude	Other	Total
Subtotal	50	0	0	0	50	100
Basic Proficiency	10	0	0	0	10	20
Specialized Proficiency	40	0	0	0	40	80
Cross Area Proficiency	0	0	0	0	0	0