Biochemistry Ⅱ

Course Information

College	Toyama College	Year	2022
Course Title	Biochemistry Ⅱ
Course Code	0109	Course Category	Specialized / Elective
Class Format	Lecture	Credits	Academic Credit: 1
Department	Department of Applied Chemistry and Chemical Engineering	Student Grade	4th
Term	Second Semester	Classes per Week	後期:2
Textbook and/or Teaching Materials
Instructor	Goto Michimasa

Course Objectives

At the completion of this course, students will be able to

1) Can explain constitution, structure, physical properties, and roles of fatty acids and lipids
2) Can explain constitution, structure, and roles of nucleotides
3) Can explain constitution, structure, specificities of enzymes and reaction mechanism of enzyme hydrolysis
4) Can explain enzyme kinetics (Michaelis-Menten equation)
5) Can explain inhibition patterns with enzyme inhibitors
6) Can explain definition and action mechanism of allosteric enzymes
7) Can explain the relationship between coenzyme and vitamin

Rubric

	Ideal Level of Achievement	Standard Level of Achievement	Unacceptable Level of Achievement)
Evaluation 1	Can explain constitution, structure, physical properties, and roles of fatty acids and lipids almost perfectly	Can explain constitution, structure, physical properties, and roles of fatty acids and lipids correctly	Can’t explain constitution, structure, physical properties, and roles of fatty acids and lipids correctly
Evaluation 2	Can explain constitution, structure, and roles of nucleotides almost perfectly	Can explain constitution, structure, and roles of nucleotides correctly	Can’t explain constitution, structure, and roles of nucleotides correctly
Evaluation 3	Can explain constitution, structure, specificities of enzymes and reaction mechanism of enzyme hydrolysis almost perfectly	Can explain constitution, structure, specificities of enzymes and reaction mechanism of enzyme hydrolysis correctly	Can’t explain constitution, structure, specificities of enzymes and reaction mechanism of enzyme hydrolysis correctly
Evaluation 4	Canexplain enzyme kinetics (Michaelis-Menten equation) almost perfectly	Can explain enzyme kinetics (Michaelis-Menten equation) correctly	Can’t explain enzyme kinetics (Michaelis-Menten equation) correctly
Evaluation 5	Can explain inhibition patterns with enzyme inhibitors almost perfectly	Can explain inhibition patterns with enzyme inhibitors correctly	Can’t explain inhibition patterns with enzyme inhibitors correctly
Evaluation 6	Can explain definition and action mechanism of allosteric enzymes almost perfectly	Can explain definition and action mechanism of allosteric enzymes correctly	Can’t explain definition and action mechanism of allosteric enzymes correctly
Evaluation 7	Can explain the relationship between coenzyme and vitamin almost perfectly	Can explain the relationship between coenzymes and vitamins correctly	Can’t explain the relationship between coenzyme and vitamin correctly

Assigned Department Objectives

学習・教育到達度目標 A-2 （設計・システム，情報・論理，材料・バイオ，力学，社会技術に関する基礎知識を理解し，簡単に説明することができる。）

JABEE 1(2)(d)(1) （専門工学（工学（融合複合・新領域）における専門工学の内容は申請高等教育機関が規定するものとする）の知識と能力）

JABEE 1(2)(d)(2) （いくつかの工学の基礎的な知識・技術を駆使して実験を計画・遂行し、データを正確に解析し、工学的に考察し、かつ説明・説得する能力）

JABEE 2.1(1) （基礎工学として、①設計・システム系科目群、②情報・論理系科目群、③材料・バイオ系科目群、④力学系科目群、⑤社会技術系科目群の５群からなり、各群から少なくとも１科目、合計最低６科目を含むこと。）

ディプロマポリシー 1 （物質 化学の中心分野である有機化学，無機化学，分析化学，物理化学，生物化学の知識・技術を身につけ，それらを応用した物質創成や技術の開発ができる。）

ディプロマポリシー 2 （課題発見能力，課題解決能力，プレゼンテーション能力を持ち，他者と協働できる。）

ディプロマポリシー 3 （豊かな教養と倫理観を身につけ，社会に貢献できる。）

Teaching Method

Outline:

The purpose of this subject is to cultivate the academic ability to understand and presume biological reactions by learning about the structure, physical properties, reactivity of lipids, nucleotides, enzymes, coenzymes and vitamins as constituent units of living systems. It is desired that you can see biological reactions based on
perspectives of organic chemistry.

Style:

Lecture
Preparatory learning: Review the previous lecture and prepare for this lesson before attending the lesson.
Out-of-class learning / advance: Prepare for lesson content.
Out-of-class learning / post-class: Review the lesson content.

Notice:

In any case, review related subjects previously learned on your own. The lecture schedule may be changed when if you have a poor understanding of the subjects. Mini-exams will be conducted once every three lectures.
1) The implementation status of self-study will be checked by taking a quiz once every three times during the lecture. The quiz shall account for 20% of the grades at the end of the term.
2) Class plans may change depending on student understanding.
3) In this subject, credits will be awarded with an evaluation of 60 points or more.
4) Can makeup exam in need aid up to maximum of 60 points.

Course Plan

			Theme	Goals
2nd Semester
	3rd Quarter
		1st	Lipids(1)	Can explain the classification of lipids, and physical properties of natural fatty acids
		2nd	Lipids(2)	Can explain structure, characteristics, and physiological roles of simple lipids
		3rd	Lipids(3)	Can explain structure, characteristics, physiological roles of phospholipids
		4th	Lipids(4)	Can explain structure, characteristics, physiological roles of glycolipids
		5th	Lipids(5)	Can explain terpenes and steroids as isoprenoids
		6th	Nucleotides	Can explain the functions and roles of nucleosides and nucleotides as constituents of nucleic acid
		7th	Enzymes (1)	Can explain constitution, classification, specificities, and nomenclature of enzymes
		8th	Midterm exam	Midterm examination
	4th Quarter
		9th	Enzymes (2)	Can explain the structure and catalytic mechanism of enzymes
		10th	Enzymes(3)	Can explain Michaelis-Menten equation and Lineweaver-Burk plot on enzyme kinetics
		11th	Enzymes(4)	Can explain classification, inhibition patterns of enzyme inhibitors, and effects on Km, Vmax and enzyme activity with enzyme inhibitors
		12th	Enzymes(5)	Can explain allosteric enzymes, immobilized enzyme and its application
		13th	Coenzymes and vitamins(1)	Can explain water-soluble and fat-soluble vitamins
		14th	Coenzymes and vitamins(2)	Can explain the relationship between coenzyme and vitamin
		15th	Final exam	Final examination
		16th	Exam explanation and questionnaire	Summarize the study content and confirm grades

Evaluation Method and Weight (%)

	Examination	Presentation	Mutual Evaluations between students	Behavior	Portfolio	Other	Total
Subtotal	80	0	0	0	20	0	100
Basic Ability	0	0	0	0	0	0	0
Technical Ability	80	0	0	0	20	0	100
Interdisciplinary Ability	0	0	0	0	0	0	0